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It's a fast onset of action with a median time to peak focus of 1 hour. The half-life from the drug has A selection of twenty-50 hours that is prolonged even even further by an active metabolite, reaching up to a one hundred-hour half-life.The metabolites of the drug may perhaps have much longer half-life at the same time. Nordiazepam, for example,

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In people currently acquiring an opioid analgesic, prescribe a decrease initial dose of the benzodiazepine or other CNS depressant than indicated from the absence of an opioid, and titrate based upon clinical reaction. If an opioid analgesic is initiated within a affected individual previously using a benzodiazepine or other CNS depressant, prescri

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